Henson was fouled by Maryland's Ashton Pankey at the 14:59 mark and used his left hand to brace fall.
The junior forward told the coaching staff that he wanted to try to continue playing, but quickly realized the pain was too severe.
"When Kendall threw that pass to me, it hurt to catch it and I couldn't even shoot it, so that's when I knew that I probably couldn't help the team," Henson said.
Henson subbed out at the 13:51 mark and did not return. X-rays taken at the arena at halftime were negative.
The first-team All-ACC performer is right-handed, but his dominant hand is his left.
"I like the left-hand hook, so it's not the hand for me to hurt, to say the least," Henson said.
When asked about playing on Saturday, Henson replied: "Just wait and see. We're going to ice it and see what happens."
The ACC's Defensive Player for the second straight season, Henson led the conference in both rebounding (10.3) and blocked shots (3.0), to go with 14.3 points per game, making him the only player in the league averaging a double-double.
In Henson's absence, freshman James Michael McAdoo played a season-high 29 minutes, recording a season-high 14 points and team-high 8 rebounds.